A new hydroxylated nonaprenylhydroquinone from the Mediterranean marine sponge Sarcotragus spinosulus

Mar Drugs. 2011;9(7):1210-1219. doi: 10.3390/md9071210. Epub 2011 Jul 7.

Abstract

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.

Keywords: Sarcotragus spinosulus; bioactivity; hydroxylated polyprenylhydroquinone; marine natural products; sponges.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydroquinones / chemistry*
  • Hydroquinones / isolation & purification
  • Hydroquinones / metabolism
  • Hydroquinones / pharmacology
  • Hydroxylation
  • Inhibitory Concentration 50
  • K562 Cells
  • Molecular Structure
  • Oceans and Seas
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / metabolism
  • Plant Extracts / pharmacology*
  • Porifera / chemistry*

Substances

  • Antineoplastic Agents
  • Hydroquinones
  • Plant Extracts