Abstract
The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC(50) values for melanin biosynthesis inhibition were 1.8 and 2.3 µg/mL for 1 and 2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Artemisia / chemistry*
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Cell Survival / drug effects
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Melanins / antagonists & inhibitors*
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Melanins / biosynthesis
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Melanoma, Experimental / drug therapy*
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Melanoma, Experimental / pathology
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Mice
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Polyunsaturated Alkamides* / chemistry
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Polyunsaturated Alkamides* / isolation & purification
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Polyunsaturated Alkamides* / pharmacology
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Skin Neoplasms / drug therapy*
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Skin Neoplasms / pathology
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Tumor Cells, Cultured
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alpha-MSH / antagonists & inhibitors*
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alpha-MSH / metabolism
Substances
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Melanins
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Plant Extracts
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Polyunsaturated Alkamides
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alpha-MSH