Abstract
The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol, ellagic acid, β-caryophyllene, myrcene, and xanthohumol. A luciferase assay revealed that ellagic acid and trans-resveratrol activated both human and mouse CAR. Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclic Monoterpenes
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Alcohol Drinking / metabolism*
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Alcoholic Beverages / analysis*
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Alkenes / pharmacology
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Animals
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Constitutive Androstane Receptor
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Ellagic Acid / pharmacology
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Energy Metabolism / drug effects*
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Flavonoids / pharmacology
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Genes, Reporter
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Hep G2 Cells
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Humans
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Luciferases / analysis
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Mice
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Monoterpenes / pharmacology
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Plasmids
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Polycyclic Sesquiterpenes
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Polyphenols / pharmacology*
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Propiophenones / pharmacology
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Receptors, Cytoplasmic and Nuclear / agonists*
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Cytoplasmic and Nuclear / metabolism
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Resveratrol
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Risk Reduction Behavior
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Sesquiterpenes / pharmacology
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Stilbenes / pharmacology
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Transfection
Substances
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Acyclic Monoterpenes
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Alkenes
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Constitutive Androstane Receptor
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Flavonoids
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Monoterpenes
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Polycyclic Sesquiterpenes
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Polyphenols
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Propiophenones
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Receptors, Cytoplasmic and Nuclear
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Sesquiterpenes
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Stilbenes
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Ellagic Acid
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myrcene
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caryophyllene
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Luciferases
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Resveratrol
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xanthohumol