Abstract
A new herbal product advertised as potency pill was sent for analysis by the local authority. The product was tested for the presence of potential derivatives of PDE-5 inhibitors, such as sildenafil, vardenafil, and tadalafil. Sildenafil analogues were identified, in which the piperazine ring and the sulfonyl group were replaced by a piperazinone and a hydroxyethyl structure, respectively. The chemical structures were established by LC-MS in ESI negative mode, UV and NMR spectroscopy (including DEPT, HSQC, HMBC, H,H-COSY, H,H-TOCSY and H,H-NOESY experiments). This is the first report of piperazinonafil and isopiperazinonafil as adulterant in an herbal food supplement.
Copyright © 2011 Elsevier B.V. All rights reserved.
MeSH terms
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Carbolines / analysis*
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Carbolines / chemistry
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Dietary Supplements / analysis*
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Drug Contamination
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Food Contamination*
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Humans
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Imidazoles / analysis*
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Imidazoles / chemistry
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Male
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Phosphodiesterase 5 Inhibitors / analysis*
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Phosphodiesterase 5 Inhibitors / chemistry
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Piperazines / analysis*
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Piperazines / chemistry
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Plant Preparations / analysis*
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Plant Preparations / chemistry
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Purines / analysis
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Purines / chemistry
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Sildenafil Citrate
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Sulfones / analysis*
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Sulfones / chemistry
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Tadalafil
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Triazines / analysis
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Triazines / chemistry
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Vardenafil Dihydrochloride
Substances
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Carbolines
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Imidazoles
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Phosphodiesterase 5 Inhibitors
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Piperazines
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Plant Preparations
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Purines
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Sulfones
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Triazines
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Vardenafil Dihydrochloride
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Tadalafil
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Sildenafil Citrate