Synthesis and structural investigations of functionalizable hybrid β-hairpin

Org Lett. 2011 Sep 2;13(17):4482-5. doi: 10.1021/ol201840p. Epub 2011 Aug 4.

Abstract

The solution and solid state conformations of a designed β-hairpin containing functionalizable α,β-unsaturated γ-amino acids at the antiparallel β-strands and a single step transformation to its saturated γ-peptide analogue are studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry*
  • Protein Conformation
  • Stereoisomerism

Substances

  • Amino Acids
  • Peptides