Ti-amide catalyzed synthesis of cyclic guanidines from di-/triamines and carbodiimides

Hao Shen; Yang Wang; Zuowei Xie

doi:10.1021/ol201752e

Ti-amide catalyzed synthesis of cyclic guanidines from di-/triamines and carbodiimides

Org Lett. 2011 Sep 2;13(17):4562-5. doi: 10.1021/ol201752e. Epub 2011 Aug 4.

Authors

Hao Shen¹, Yang Wang, Zuowei Xie

Affiliation

¹ Department of Chemistry and State Key Laboratory on Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

PMID: 21815662
DOI: 10.1021/ol201752e

Abstract

A titanacarborane monoamide catalyzed, one-step synthesis of mono/bicyclic guanidines from commercially available di/triamines and carbodiimides is reported. The reaction mechanism is also proposed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Catalysis
Crystallography, X-Ray
Guanidines / chemical synthesis*
Guanidines / chemistry
Imides / chemistry*
Models, Molecular
Molecular Structure
Organometallic Compounds / chemistry*
Stereoisomerism
Titanium / chemistry*

Substances

Amides
Guanidines
Imides
Organometallic Compounds
Titanium