Limonoids from Meliaceae with lipid peroxidation inhibitory activity

Robert G Fowles; Baldwin S Mootoo; Russel S Ramsewak; William F Reynolds; Muraleedharan G G Nair

Limonoids from Meliaceae with lipid peroxidation inhibitory activity

Nat Prod Commun. 2011 Jun;6(6):785-7.

Authors

Robert G Fowles¹, Baldwin S Mootoo, Russel S Ramsewak, William F Reynolds, Muraleedharan G G Nair

Affiliation

¹ Department of Agricultural, Food and Nutritional Science, T6G 2P5, University of Alberta, Edmonton, Alberta, Canada.

PMID: 21815411

Abstract

In this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semi-synthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6% inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semi-synthetic analogues 10 (98.3%), 16-17, 21-22 and 25 (100%), which were more active than the positive controls BHA (91.3%) and TBHQ (95.7%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / chemistry*
Antioxidants / pharmacology*
Limonins / chemistry*
Limonins / pharmacology*
Lipid Peroxidation / drug effects*
Meliaceae / chemistry*
Molecular Structure

Substances

Antioxidants
Limonins