Abstract
A copper-catalyzed thiolation annulation reaction of 2-bromo alkynylbenzenes with sodium sulfide has been developed. In the presence of CuI and TMEDA, a variety of 2-substituted benzo[b]thiophenes were readily prepared in moderate to good yields by the reaction of 2-bromo alkynylbenzenes and Na(2)S·9H(2)O.
© 2011 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzene / chemistry*
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Catalysis
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Chromatography, Thin Layer
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Gas Chromatography-Mass Spectrometry
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Magnetic Resonance Spectroscopy
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Organometallic Compounds / chemistry*
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Spectrophotometry, Infrared
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Sulfides / chemistry*
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Thiophenes / chemical synthesis*
Substances
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Organometallic Compounds
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Sulfides
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Thiophenes
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phenyllithium
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Benzene
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sodium sulfide