Abstract
A new diterpene glycoside, tomentoside I (1), along with eleven known compounds, including the four coumarins, 4,5-dimethoxyl-7-methylcoumarin (2), 4,7-dimethoxyl-5-methylcoumarin (3), isofraxidin (4) and fraxidin (5) as well as the seven triterpenoids, oleanolic acid (6), oleanolic acid 3-O-α-L-arabinopyranoside (7), oleanolic acid 3-O-β-D-galactopyranosyl-(1→3)-β-D-glucopyranoside (8), hederagenin 3-O-α-L-arabinopyranoside (9), betulinic acid (10), 18-hydroxyursolic acid (11) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (12) were isolated from the ethanolic extract of the root of Anemone tomentosa and their chemical structures were elucidated by spectroscopic methods. The antimicrobial activities of compounds 1-12 were measured using the agar disc-diffusion method. Also, their antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anemone / chemistry
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Anemone / metabolism*
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Betulinic Acid
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Coumarins / chemical synthesis
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Coumarins / chemistry
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Coumarins / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / pharmacology*
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification
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Free Radical Scavengers / pharmacology
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Glycosides / chemical synthesis
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Microbial Sensitivity Tests
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Pentacyclic Triterpenes
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Phytosterols / chemical synthesis
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Phytosterols / chemistry
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Phytosterols / pharmacology
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Phytotherapy
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Plant Roots / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / pharmacology
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Sterols / chemistry
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Sterols / isolation & purification
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Sterols / pharmacology
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Structure-Activity Relationship
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Triterpenes / chemical synthesis
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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Coumarins
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Drugs, Chinese Herbal
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Free Radical Scavengers
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Glycosides
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Pentacyclic Triterpenes
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Phytosterols
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Saponins
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Sterols
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Triterpenes
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hederagenin 3-O-alpha-L-arabinopyranoside
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Oleanolic Acid
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Betulinic Acid