Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages

Jun Li; Chun-Ru Liao; Jun-Qi Wei; Li-Xia Chen; Feng Zhao; Feng Qiu

doi:10.1016/j.bmcl.2011.07.012

Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5363-9. doi: 10.1016/j.bmcl.2011.07.012. Epub 2011 Jul 18.

Authors

Jun Li¹, Chun-Ru Liao, Jun-Qi Wei, Li-Xia Chen, Feng Zhao, Feng Qiu

Affiliation

¹ Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

PMID: 21807513
DOI: 10.1016/j.bmcl.2011.07.012

Abstract

Eleven diarylheptanoids (1-11) were isolated from rhizomes of Curcuma kwangsiensis, together with seven known compounds. Their structures were elucidated by 1D and 2D NMR, circular dichroism (CD), and accurate mass measurements. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 1, 2, and 3 showed strong inhibitory activity on NO production with IC(50) values of 3.13, 2.81 and 2.41 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Curcuma / chemistry*
Diarylheptanoids / chemistry
Diarylheptanoids / isolation & purification
Diarylheptanoids / pharmacology*
Dose-Response Relationship, Drug
Lipopolysaccharides / pharmacology
Macrophages / chemistry
Macrophages / drug effects*
Macrophages / metabolism
Magnetic Resonance Spectroscopy
Molecular Structure
Nitric Oxide / antagonists & inhibitors*
Nitric Oxide / biosynthesis
Stereoisomerism
Structure-Activity Relationship

Substances

Diarylheptanoids
Lipopolysaccharides
Nitric Oxide