This cross sectional study was done for the evaluation of the risk factors of oral cancer. This study was carried out in the department of Otolaryngology-Head & Neck Surgery of Bangabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital, Dhaka, Bangladesh. A total of 90 consecutive patients with oral squamous cell carcinoma (OSCC) were studied in Otolaryngology department of BSMMU and DMCH from January 2003 to December 2005. A questionnaire was used for data collection from careful history taking, clinical examination and investigations. About 71.1% were habituated with betel quid chewing, 36.7% were habituated with smoking but among 23.3 % also betel quid chewer in addition. None of the patient was found to be habituated with alcohol consumption. Majority of the patients of OSCC were malnourished, of which female were more in number, and it was found that nutritional status was significantly associated with sex. Odds ratio (OD) showed that malnutrition was positively associated with female subjects. Also it was found that 69.01% betel quid chewer was malnourished and nutritional status was significantly associated with chewing and smoking habit. Betel quid chewing, smoking and malnutrition is important risk factor of oral cancer.