Finding the missing code of RNA recognition by PUF proteins

Yu Chen; Gabriele Varani

doi:10.1016/j.chembiol.2011.07.001

Finding the missing code of RNA recognition by PUF proteins

Chem Biol. 2011 Jul 29;18(7):821-3. doi: 10.1016/j.chembiol.2011.07.001.

Authors

Yu Chen¹, Gabriele Varani

Affiliation

¹ Department of Chemistry, University of Washington, Seattle, WA 98195, USA.

Abstract

Pumilio and FBF homology (PUF) proteins represent highly promising candidates for engineering sequence-specific RNA recognition, but were only known to recognize G, A, and U, significantly limiting applications. Two groups (Filipovska et al., 2011; Dong et al., 2011) have now reported the discovery of the cytosine-recognition code for PUF proteins.

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