Multidrug-resistant pandemic (H1N1) 2009 infection in immunocompetent child

Emerg Infect Dis. 2011 Aug;17(8):1472-4. doi: 10.3201/eid1708.102004.

Abstract

Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation. We report a case of multidrug-resistant pandemic (H1N1) 2009 bearing the I223R mutation in an ambulatory child with no previous exposure to neuraminidase inhibitors.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antiviral Agents / pharmacology*
  • Drug Resistance, Multiple, Viral / genetics*
  • Enzyme Inhibitors / pharmacology
  • Female
  • Humans
  • Immunocompetence*
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / enzymology
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza, Human / drug therapy*
  • Influenza, Human / virology
  • Mutation
  • Neuraminidase / genetics
  • Oseltamivir / pharmacology*
  • Pandemics*
  • Zanamivir / pharmacology*

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • Oseltamivir
  • Neuraminidase
  • Zanamivir