Abstract
Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation. We report a case of multidrug-resistant pandemic (H1N1) 2009 bearing the I223R mutation in an ambulatory child with no previous exposure to neuraminidase inhibitors.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antiviral Agents / pharmacology*
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Drug Resistance, Multiple, Viral / genetics*
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Enzyme Inhibitors / pharmacology
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Female
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Humans
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Immunocompetence*
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Influenza A Virus, H1N1 Subtype / drug effects*
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Influenza A Virus, H1N1 Subtype / enzymology
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Influenza A Virus, H1N1 Subtype / genetics
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Influenza A Virus, H1N1 Subtype / isolation & purification
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Influenza, Human / drug therapy*
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Influenza, Human / virology
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Mutation
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Neuraminidase / genetics
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Oseltamivir / pharmacology*
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Pandemics*
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Zanamivir / pharmacology*
Substances
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Antiviral Agents
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Enzyme Inhibitors
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Oseltamivir
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Neuraminidase
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Zanamivir