Total synthesis of the natural product (±)-dibromophakellin and analogues

Org Lett. 2011 Sep 2;13(17):4550-3. doi: 10.1021/ol201741r. Epub 2011 Jul 28.

Abstract

(±)-Dibromophakellin has been synthesized in two steps from a known alkene intermediate. The key step in the synthesis is the NBS olefin activation to facilitate the addition of a guanidine molecule across the double bond.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Factors / chemical synthesis*
  • Biological Factors / chemistry
  • Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Biological Factors
  • Heterocyclic Compounds, 4 or More Rings
  • dibromophakellin