Abstract
Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in addition to which it has shown to be a predictor of severity in patients with rheumatoid arthritis, suggesting an important participation in the pathogenesis of the disease.
Copyright © 2009 Elsevier España, S.L. All rights reserved.
MeSH terms
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Animals
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Antibody Specificity
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Arginine / metabolism
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Arthritis, Rheumatoid / blood
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Arthritis, Rheumatoid / diagnosis
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Arthritis, Rheumatoid / immunology*
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Arthritis, Rheumatoid / metabolism
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Autoantibodies / blood
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Autoantibodies / immunology*
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Autoantigens / immunology*
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Autoantigens / metabolism
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Biomarkers
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Biomarkers, Tumor / immunology
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Biomarkers, Tumor / metabolism
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Citrulline / metabolism*
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Collagen Type II / immunology
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Collagen Type II / metabolism
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DNA-Binding Proteins / immunology
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DNA-Binding Proteins / metabolism
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Disease Models, Animal
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Fibrinogen / immunology
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Fibrinogen / metabolism
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Humans
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Hydrolases / metabolism
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Phosphopyruvate Hydratase / immunology
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Phosphopyruvate Hydratase / metabolism
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Protein Processing, Post-Translational*
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Protein-Arginine Deiminase Type 4
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Protein-Arginine Deiminases
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Rats
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Rats, Inbred Lew
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Sensitivity and Specificity
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Substrate Specificity
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Tumor Suppressor Proteins / immunology
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Tumor Suppressor Proteins / metabolism
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Vimentin / immunology
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Vimentin / metabolism
Substances
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Autoantibodies
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Autoantigens
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Biomarkers
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Biomarkers, Tumor
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Collagen Type II
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DNA-Binding Proteins
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Tumor Suppressor Proteins
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Vimentin
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Citrulline
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Fibrinogen
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Arginine
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Hydrolases
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PADI4 protein, human
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Protein-Arginine Deiminase Type 4
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Protein-Arginine Deiminases
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ENO1 protein, human
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Phosphopyruvate Hydratase