Polypharmacy and medication-related complications in the chronic kidney disease patient

Curr Opin Nephrol Hypertens. 2011 Sep;20(5):492-7. doi: 10.1097/MNH.0b013e328349c261.

Abstract

Purpose of review: Medication-related problems are very common in patients with chronic kidney disease (CKD). Identification, prevention and management of these problems require a comprehensive, interdisciplinary approach. This article reviews the recent literature regarding medication-related problems in CKD and proposes initiatives for addressing these problems through a structured review process and use of patient-centered adherence-promoting strategies.

Recent findings: Pharmacist-conducted medication review and intervention programs are successful at identifying and resolving medication-related problems in CKD patients. These programs are associated with a reduction in the number of medications and frequency of hospitalization, and are associated with maintenance of quality of life. However, adherence continues to be a major medication-related problem in CKD care.

Summary: Structured medication review and assessment of adherence assist in identification and resolution of medication-related problems in CKD. More research is needed on successful methods to improve medication adherence and related health outcomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chronic Disease
  • Drug Interactions
  • Drug-Related Side Effects and Adverse Reactions*
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Kidney Diseases / complications
  • Kidney Diseases / drug therapy*
  • Medication Adherence
  • Medication Errors / prevention & control
  • Medication Reconciliation
  • Patient Education as Topic
  • Polypharmacy