F33:A-:B- and F2:A-:B- plasmids mediate dissemination of rmtB-blaCTX-M-9 group genes and rmtB-qepA in Enterobacteriaceae isolates from pets in China

Antimicrob Agents Chemother. 2011 Oct;55(10):4926-9. doi: 10.1128/AAC.00133-11. Epub 2011 Jul 25.

Abstract

This study investigated the prevalence of 16S rRNA methylase genes in 267 Enterobacteriaceae isolates collected from pets. The rmtB gene was detected in 69 isolates, most of which were clonally unrelated. The coexistence of the rmtB gene with the bla(CTX-M-9) group genes and/or qepA within the same IncFII replicons was commonly detected. The two dominant types of IncF plasmids, F2:A-:B-, carrying rmtB-qepA, and F33:A-:B-, carrying the rmtB-bla(CTX-M-9) group genes (and especially bla(CTX-M-65)), shared restriction patterns within each incompatibility group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides / pharmacology
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Cats
  • China
  • Dogs
  • Drug Resistance, Multiple, Bacterial
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae / isolation & purification
  • Escherichia coli Proteins / genetics*
  • Gene Transfer, Horizontal
  • Methyltransferases / genetics*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Pets / microbiology*
  • Plasmids / genetics*
  • RNA, Ribosomal, 16S / genetics
  • beta-Lactamases / genetics*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Escherichia coli Proteins
  • QepA protein, E coli
  • RNA, Ribosomal, 16S
  • Methyltransferases
  • RmtB protein, E coli
  • CTX-M-9 protein, E coli
  • beta-Lactamases

Associated data

  • GENBANK/GU477621
  • GENBANK/HQ706665
  • GENBANK/HQ706666
  • GENBANK/HQ706667
  • GENBANK/HQ882837
  • GENBANK/HQ882838
  • GENBANK/HQ882839