Abstract
Continued chemical investigation on the fruits of Aesculus pavia L. resulted in theisolation and identification of two new oleanolic acid saponins, namely vaccaroside A (1) andvaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays.In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC₅₀ valuesin the range of 27.80-79.02 μM.
Copyright © 2011 Elsevier B.V. All rights reserved.
MeSH terms
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Aesculus / chemistry*
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Amniotic Fluid
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Cell Line
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Fruit
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Humans
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Lung Neoplasms / drug therapy*
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Oleanolic Acid / therapeutic use
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Saponins / isolation & purification
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Saponins / pharmacology
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Saponins / therapeutic use*
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Saponins
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vaccaroside A
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vaccaroside B
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Oleanolic Acid