Palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates with aryl halides

Rui Shang; Zheng Huang; Ling Chu; Yao Fu; Lei Liu

doi:10.1021/ol201750s

Palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates with aryl halides

Org Lett. 2011 Aug 19;13(16):4240-3. doi: 10.1021/ol201750s. Epub 2011 Jul 26.

Authors

Rui Shang¹, Zheng Huang, Ling Chu, Yao Fu, Lei Liu

Affiliation

¹ Department of Chemistry, Joint Laboratory of Green Synthetic Chemistry, University of Science and Technology of China, Hefei 230026, China.

PMID: 21786835
DOI: 10.1021/ol201750s

Abstract

A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes and their derivatives.