Abstract
A concise method for the formation of cyclopyrophosphate of cIDPRE as well as sulfur and selenium-substituted pyrophosphate cIDPRE analogues (P(1)(S)-cIDPRE, P(1)(Se)-cIDPRE, P(2)(S)-cIDPRE and P(2)(Se)-cIDPRE) was reported and one of the P(S)-diastereoisomers, P(1)(S)-cIDPRE-1, is a novel membrane-permeant cADPR antagonist.
This journal is © The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calcium Channel Blockers / chemical synthesis
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Calcium Channel Blockers / chemistry
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Cyclic ADP-Ribose / analogs & derivatives*
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Diphosphates / chemistry*
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Inosine Monophosphate / analogs & derivatives
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Inosine Monophosphate / chemical synthesis
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Inosine Monophosphate / chemistry
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Molecular Conformation
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Ryanodine Receptor Calcium Release Channel / chemistry
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Ryanodine Receptor Calcium Release Channel / metabolism
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Selenium / chemistry
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Stereoisomerism
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Sulfur / chemistry
Substances
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Calcium Channel Blockers
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Diphosphates
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N(1)-((5''-O-phosphorylethoxy)methyl)-5'-O-phosphorylinosine 5',5''-cyclic pyrophosphate
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Ryanodine Receptor Calcium Release Channel
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Cyclic ADP-Ribose
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Inosine Monophosphate
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Sulfur
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Selenium