Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats

Maria E Carou; Osvaldo J Ponzo; Romina P Cardozo Gutierrez; Berta Szwarcfarb; Maria L Deguiz; Roxana Reynoso; Silvia Carbone; Jaime A Moguilevsky; Pablo Scacchi

doi:10.1016/j.etap.2008.04.001

Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats

Environ Toxicol Pharmacol. 2008 Sep;26(2):222-4. doi: 10.1016/j.etap.2008.04.001. Epub 2008 Apr 11.

Authors

Maria E Carou¹, Osvaldo J Ponzo, Romina P Cardozo Gutierrez, Berta Szwarcfarb, Maria L Deguiz, Roxana Reynoso, Silvia Carbone, Jaime A Moguilevsky, Pablo Scacchi

Affiliation

¹ Department of Physiology, Medicine School, University of Buenos Aires (UBA), Buenos Aires, Argentina.

PMID: 21783915
DOI: 10.1016/j.etap.2008.04.001

Abstract

4-Methylbenzylidene camphor (4-MBC) is an ultraviolet absorbent. The objective of this paper was to evaluate the effect of 4-MBC low-dose exposure on the neuroendocrine reproductive regulation in male rats. Wistar male adult rats were injected sc. with 4-MBC during 5 days with a dose of 2 and 10mg/kg or during 2 days with a dose of 2 and 20mg/kg. In all rats serum prolactin, LH and FSH concentration were assayed. The hypothalamus of rats injected during 2 days were also dissected to study GnRH release. Rats that received 2 and 10mg/kg of 4-MBC during 5 days showed a decrease in the LH and FSH serum concentration. In rats injected during 2 days, serum LH decreased with 2 and 20mg/kg and FSH decreased with 2mg/kg of 4-MBC. In vitro hypothalamic GnRH release also decreased in these animals. These results show that low doses of 4-MBC inhibit the reproductive axis in adult male rats.