Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart

Branka I Ognjanović; Snežana D Marković; Sladjan Z Pavlović; Radoslav V Zikić; Andraš Š Stajn; Zorica S Saičić

doi:10.1016/j.etap.2006.03.008

Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart

Environ Toxicol Pharmacol. 2006 Sep;22(2):219-24. doi: 10.1016/j.etap.2006.03.008. Epub 2006 May 18.

Authors

Branka I Ognjanović¹, Snežana D Marković, Sladjan Z Pavlović, Radoslav V Zikić, Andraš Š Stajn, Zorica S Saičić

Affiliation

¹ Institute of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, 34000 Kragujevac, Serbia and Montenegro.

PMID: 21783713
DOI: 10.1016/j.etap.2006.03.008

Abstract

Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4mg Cd/kg BW i.p.), CoQ(10) (20mg CoQ(10)/kg BW i.m.) and Vit E (20IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ(10) and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ(10) and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart.