Isolation and structural elucidation of two secondary metabolites from the filamentous fungus Penicillium ochrochloron with antimicrobial activity

Ana Rančić; Marina Soković; Anastasia Karioti; Jelena Vukojević; Helen Skaltsa

doi:10.1016/j.etap.2005.12.003

Isolation and structural elucidation of two secondary metabolites from the filamentous fungus Penicillium ochrochloron with antimicrobial activity

Environ Toxicol Pharmacol. 2006 Jul;22(1):80-4. doi: 10.1016/j.etap.2005.12.003. Epub 2006 Jan 26.

Authors

Ana Rančić¹, Marina Soković, Anastasia Karioti, Jelena Vukojević, Helen Skaltsa

Affiliation

¹ Department of Plant Physiology, Mycological Laboratory, Institute for Biological Research, Bulevar despota Stefana 142, 11 000 Belgrade, Serbia and Montenegro.

PMID: 21783691
DOI: 10.1016/j.etap.2005.12.003

Abstract

In this investigation, the extracts of filamentous fungi exhibited inhibitory effect on the growth of Gram positive and Gram negative bacteria, as well as against the yeast Candida albicans. Penicillium ochrochloron has been proven as the most active fungus against all tested microorganisms. Further bio-guided chemical analysis of P. ochrochloron afforded two components with antimicrobial activity identified as (-) 2, 3, 4-trihydroxybutanamide and (-) erythritol.