Short-term effects and teratogenicity of heptanol on embryos of Xenopus laevis

Eva Olmedo; Lidia Bardia; Jordi Domingo

doi:10.1016/j.etap.2003.11.004

Short-term effects and teratogenicity of heptanol on embryos of Xenopus laevis

Environ Toxicol Pharmacol. 2004 Jan;15(2-3):119-23. doi: 10.1016/j.etap.2003.11.004.

Authors

Eva Olmedo¹, Lidia Bardia, Jordi Domingo

Affiliation

¹ Department of Cell Biology and Pathology, Universtat de Barcelona, Campus de Bellvitge, Feixa Llarga, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

PMID: 21782688
DOI: 10.1016/j.etap.2003.11.004

Abstract

This study examined teratogenic and short-term effects of heptanol on Xenopus embryos. Embryos were exposed for 5h to 2.5mM heptanol at different developmental stages. Teratogenic effects were found in embryos treated from cleavage to early neurula stages. Other heptanol concentrations, shorter exposure time, and the effect of temperature were also assayed. Short-term effects of hepatanol exposure were studied during cleavage and all treated blastulae showed cell separation with delaminated blastomeres inside the blastocel. Disruption of cell adhesion in addition to the uncoupling effect could account for heptanol teratogenicity.