In silico prediction of transcriptional factor-binding sites

Dmitry Y Oshchepkov; Victor G Levitsky

doi:10.1007/978-1-61779-176-5_16

In silico prediction of transcriptional factor-binding sites

Methods Mol Biol. 2011:760:251-67. doi: 10.1007/978-1-61779-176-5_16.

Authors

Dmitry Y Oshchepkov¹, Victor G Levitsky

Affiliation

¹ Laboratory of Theoretical Genetics, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. diman@bionet.nsc.ru

PMID: 21780002
DOI: 10.1007/978-1-61779-176-5_16

Abstract

The recognition of transcription factor binding sites (TFBSs) is the first step on the way to deciphering the DNA regulatory code. A large variety of computational approaches and corresponding in silico tools for TFBS recognition are available, each having their own advantages and shortcomings. This chapter provides a brief tutorial to assist end users in the application of these tools for functional characterization of genes.

MeSH terms

Animals
Binding Sites / genetics
Computational Biology / methods*
Computer Simulation*
Humans
Information Storage and Retrieval
Internet
Models, Biological*
Software
Transcription Factors / metabolism*

Substances

Transcription Factors