The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

N L Harrison; D M Lovinger; N A Lambert; T J Teyler; R Prager; J Ong; D I Kerr

doi:10.1016/0304-3940(90)90851-y

The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus

Neurosci Lett. 1990 Nov 13;119(2):272-6. doi: 10.1016/0304-3940(90)90851-y.

Authors

N L Harrison¹, D M Lovinger, N A Lambert, T J Teyler, R Prager, J Ong, D I Kerr

Affiliation

¹ Department of Anesthesia and Critical Care, University of Chicago, IL 60637.

PMID: 2177868
DOI: 10.1016/0304-3940(90)90851-y

Abstract

The actions of 2-hydroxy-saclofen (2-OH-S), a recently developed analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 microM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 microM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.

MeSH terms

Animals
Baclofen / analogs & derivatives*
Baclofen / pharmacology
Electrophysiology
Hippocampus / cytology
Hippocampus / metabolism*
Hippocampus / physiology
In Vitro Techniques
Neurons / physiology
Rats
Receptors, GABA-A / drug effects*
Receptors, GABA-A / metabolism
Receptors, GABA-A / physiology
Synapses / drug effects
Synapses / metabolism*

Substances

Receptors, GABA-A
Baclofen
2-hydroxysaclofen