Abstract
Traumatic eosinophilic granuloma with stromal eosinophilia is a rare entity that affects the oral mucosa and has a controversial etiologic pathogenesis. Histologically, these lesions are characterized by a dense and deeply infiltrative lymphoproliferation showing epitheliotropic characteristics and massive eosinophilia. Frequently, a population of mitotically active, atypical mononuclear cells can be noted. This report describes a case of traumatic eosinophilic granuloma with stromal eosinophilia in the floor of the mouth of an 88-year-old man. The phenotypic and genotypic profiles of the inflammatory infiltrate and large atypical mononuclear cells, using immunohistochemical and polymerase chain reaction-based molecular analysis, were analyzed.
Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Aged, 80 and over
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DNA / analysis
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Eosinophilic Granuloma / diagnosis*
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Eosinophilic Granuloma / pathology
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Eosinophils / pathology
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Follow-Up Studies
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Gene Rearrangement / genetics
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Gene Rearrangement, B-Lymphocyte / genetics
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Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / genetics
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Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / genetics
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Genes, Immunoglobulin Heavy Chain / genetics
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Humans
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Immunoglobulin Variable Region / genetics
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Immunohistochemistry
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Male
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Mouth Diseases / diagnosis*
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Mouth Diseases / pathology
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Mouth Floor / pathology
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Mouth Mucosa / injuries*
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Oral Ulcer / diagnosis*
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Oral Ulcer / pathology
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Polymerase Chain Reaction
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Stromal Cells / pathology
Substances
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Immunoglobulin Variable Region
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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DNA