Dieulafoy's lesion is an uncommon cause of brisk arterial bleeding from the gastrointestinal tract that can have severe consequences such as rebleeding and hypotension if left untreated. The authors report the case of an elderly woman with several comorbidities who presented with duodenal bleeding caused by a Dieulafoy lesion. The lesion was treated endoscopically and was subsequently complicated by the formation of a retroperitoneal hematoma. Given the surgical risk, the authors opted to retreat endoscopically, which proved to be a reasonable approach in this particular patient.
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