A nonlinear three-compartment model for the administration of 2',3'-dideoxycytidine by using red blood cells as bioreactors

Bull Math Biol. 1990;52(6):785-96. doi: 10.1007/BF02460809.

Abstract

A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2',3'-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Numerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Delayed-Action Preparations
  • Drug Carriers
  • Erythrocytes / metabolism
  • HIV Infections / blood
  • HIV Infections / drug therapy
  • Humans
  • Models, Biological
  • Zalcitabine / administration & dosage*
  • Zalcitabine / blood

Substances

  • Delayed-Action Preparations
  • Drug Carriers
  • Zalcitabine