Different epidemiological studies show the relationship between osteoporosis, cardiovascular disease, and cardiovascular-related mortality. Previously considered as age-related but independent diseases, this review reports emerging data showing the common mechanism of both conditions. The relationship between bone-related proteins such as osteocalcin and osteoprotegerin and vascular disease is of special interest. In addition, recent data suggest the influence of bone metabolism on energy balance which may be relevant for cardiovascular disease.
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