SNARE derived peptide mimic inducing membrane fusion

Chem Commun (Camb). 2011 Sep 7;47(33):9405-7. doi: 10.1039/c1cc12879e. Epub 2011 Jul 20.

Abstract

SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Crystallography, X-Ray
  • Liposomes / chemistry
  • Membrane Fusion
  • Molecular Sequence Data
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Structure, Tertiary
  • SNARE Proteins / chemistry*
  • SNARE Proteins / metabolism
  • Syntaxin 1 / chemistry
  • Syntaxin 1 / metabolism
  • Vesicle-Associated Membrane Protein 2 / chemistry
  • Vesicle-Associated Membrane Protein 2 / metabolism

Substances

  • Liposomes
  • Peptides
  • SNARE Proteins
  • Syntaxin 1
  • Vesicle-Associated Membrane Protein 2