Use of topical brimonidine to prevent intraocular pressure elevations following Nd: YAG-laser posterior capsulotomy

Deepika Singhal; Roopali Desai; Sejal Desai; Manisha Shastri; Deepak Saxena

doi:10.4103/0976-500X.81902

Use of topical brimonidine to prevent intraocular pressure elevations following Nd: YAG-laser posterior capsulotomy

J Pharmacol Pharmacother. 2011 Apr;2(2):104-6. doi: 10.4103/0976-500X.81902.

Authors

Deepika Singhal¹, Roopali Desai, Sejal Desai, Manisha Shastri, Deepak Saxena

Affiliation

¹ Department of Ophthalmology, Surat Municipal Institute of Medical Education and Research, Surat, Indian Institute of Public Health, Gandhinagar, India.

Abstract

Objective: To study the effect of brimonidine on intraocular pressure (IOP) following capsulotomy among Indian subjects.

Materials and methods: The study was a nonrandomized trial with open label.

Results: 80% of the subjects showed a decrease in IOP after instilling 0.2% brimonidine (1 hour pre capsulotomy). No such decrease was observed in control. After 1 and 4 h post capsulotomy a statistically significant decrease in IOP ranging between 1-10 mmHg was found in 73.3% of the treatment group.

Conclusions: In the present study 0.2% brimonidine has been proven effective to counteract the increase in IOP following Nd-YAG laser capsulotomy in Indian setting.

Keywords: Brimonidine; Nd-YAG laser capsulotomy; intraocular pressure; posterior capsular opacification.