Down's syndrome: increased enzymatic antioxidative defense is accompanied by decreased superoxide anion generation in blood

J Kedziora; J Błaszczyk; E Sibińska; G Bartosz

doi:10.1111/j.1601-5223.1990.tb00699.x

Down's syndrome: increased enzymatic antioxidative defense is accompanied by decreased superoxide anion generation in blood

Hereditas. 1990;113(1):73-5. doi: 10.1111/j.1601-5223.1990.tb00699.x.

Authors

J Kedziora¹, J Błaszczyk, E Sibińska, G Bartosz

Affiliation

¹ Department of Physiology, Institute of Fundamental Sciences, WAM, Lódź, Poland.

PMID: 2177051
DOI: 10.1111/j.1601-5223.1990.tb00699.x

Abstract

Whole blood leukocytes of DS patients were found to produce less superoxide radical anion than in healthy controls, especially without stimulation with zymosan. This decreased superoxide generation may contribute to the immune system deficiency reported for DS.

MeSH terms

Adult
Catalase / metabolism
Down Syndrome / blood
Down Syndrome / enzymology*
Female
Glutathione Peroxidase / metabolism
Humans
Male
Oxidation-Reduction
Superoxide Dismutase / metabolism*
Superoxides / blood*

Substances

Superoxides
Catalase
Glutathione Peroxidase
Superoxide Dismutase