Synthesis and biological activity of optically active phenylbutenoid dimers

J Nat Prod. 2011 Aug 26;74(8):1817-21. doi: 10.1021/np100942e. Epub 2011 Jul 19.

Abstract

The total synthesis of optically active phenylbutenoid dimers 1, 3, and ent-3 is described. The key step to access optically active cyclohexene rings was achieved by Diels-Alder reaction of chiral acryloyloxazolinone 9 and phenylbetadiene 10.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzene Derivatives / chemical synthesis*
  • Benzene Derivatives / chemistry
  • Benzene Derivatives / pharmacology*
  • Butyrates / chemical synthesis*
  • Butyrates / chemistry
  • Butyrates / pharmacology*
  • Cyclohexenes / chemical synthesis*
  • Cyclohexenes / chemistry
  • Cyclohexenes / pharmacology*
  • Female
  • Humans
  • Molecular Structure
  • Stereoisomerism

Substances

  • Benzene Derivatives
  • Butyrates
  • Cyclohexenes