[Preparation of toxoid from Taiwan cobra (Naja naja atra) venom]

Zhonghua Yi Xue Za Zhi (Taipei). 1990 Jul;46(1):1-6.
[Article in Chinese]

Abstract

Potency of sixty antitoxic unit was reached after two immunizations in 2-week intervals of rabbits and horses with 10-25 mg Taiwan cobra (Naja naja atra) venom which was detoxified by 0.125% glutaraldehyde. Now this procedure has become a routine antivenine-producing method by which snake bivalent neurotropic antivenine is produced. The stability test showed that Taiwan cobra toxoid kept at 37 degrees C for 40 days, the antigenicity increased by 24% and toxicity decreased by 10% as compared to the toxoid maintained at 4 degrees C.

MeSH terms

  • Animals
  • Antivenins / biosynthesis
  • Elapid Venoms / analysis*
  • Female
  • Horses
  • Male
  • Mice
  • Mice, Inbred ICR
  • Rabbits
  • Taiwan
  • Toxoids / analysis*

Substances

  • Antivenins
  • Elapid Venoms
  • Toxoids