Oleanane-type triterpenoids from the leaves and twigs of Fatsia polycarpa

Shi-Yie Cheng; Chao-Min Wang; Yuan-Man Hsu; Tsurng-Juhn Huang; Shen-Chieh Chou; En-Hung Lin; Chang-Hung Chou

doi:10.1021/np2002435

Oleanane-type triterpenoids from the leaves and twigs of Fatsia polycarpa

J Nat Prod. 2011 Aug 26;74(8):1744-50. doi: 10.1021/np2002435. Epub 2011 Jul 19.

Authors

Shi-Yie Cheng¹, Chao-Min Wang, Yuan-Man Hsu, Tsurng-Juhn Huang, Shen-Chieh Chou, En-Hung Lin, Chang-Hung Chou

Affiliation

¹ Research Center for Biodiversity, China Medical University , Taichung 40402, Taiwan, Republic of China.

PMID: 21766884
DOI: 10.1021/np2002435

Abstract

Seven new oleanane-type triterpenoids (1-7), named fatsicarpains A-G, and the known compounds 3α-hydroxyolean-11,13(18)-dien-28-oic acid (8) and 3α-hydroxyolean-11-en-28,13β-olide (9) were isolated from the leaves and twigs of Fatsia polycarpa on the basis of bioassay-guided fractionation. The structures of compounds 1-7 were elucidated through spectroscopic analyses and single-crystal X-ray crystallography of 1, 8, and 9. Cytotoxicity against HepG2 2.2.15 and AGS cells and antihepatitis B virus (HBV) and antibacterial activities of 1-9 were also evaluated in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Araliaceae / chemistry*
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Hep G2 Cells
Hepatitis B virus / drug effects
Humans
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oleanolic Acid / analogs & derivatives*
Oleanolic Acid / chemistry
Oleanolic Acid / isolation & purification
Oleanolic Acid / pharmacology
Plant Leaves / chemistry
Plant Stems / chemistry

Substances

Antineoplastic Agents, Phytogenic
fatsicarpain A
oleanane
Oleanolic Acid