Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Shuhei Murayama; Yasufumi Imae; Kentaro Takada; Jo Kikuchi; Yoichi Nakao; Rob W M van Soest; Shigeru Okada; Shigeki Matsunaga

doi:10.1016/j.bmc.2011.06.052

Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Bioorg Med Chem. 2011 Nov 15;19(22):6594-8. doi: 10.1016/j.bmc.2011.06.052. Epub 2011 Jun 24.

Authors

Shuhei Murayama¹, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Yoichi Nakao, Rob W M van Soest, Shigeru Okada, Shigeki Matsunaga

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

PMID: 21764589
DOI: 10.1016/j.bmc.2011.06.052

Abstract

Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC(50) value of 8 μg/mL each.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cathepsin B / antagonists & inhibitors*
Cysteine Proteinase Inhibitors / chemistry
Cysteine Proteinase Inhibitors / isolation & purification
Cysteine Proteinase Inhibitors / pharmacology
Molecular Conformation
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Steroids / chemistry*
Steroids / isolation & purification
Steroids / pharmacology*

Substances

Cysteine Proteinase Inhibitors
Steroids
Cathepsin B