A new staurosporine analog from Actinomycetes Streptomyces sp. (172614)

J Asian Nat Prod Res. 2011 Aug;13(8):765-9. doi: 10.1080/10286020.2011.586342.

Abstract

A new staurosporine analog, 10'-{5″-[(methoxycarbonyl)amino]-2″-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / isolation & purification*
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Staurosporine / analogs & derivatives*
  • Staurosporine / chemistry
  • Staurosporine / isolation & purification*
  • Staurosporine / pharmacology
  • Streptomyces / chemistry*

Substances

  • 10'-(5''-((methoxycarbonyl)amino)-2'-methyl)phenylaminocarbonylstaurosporine
  • Antineoplastic Agents
  • Staurosporine