Abstract
Two neuropective compounds were isolated from the rhizomes of Abacopteris penangiana, one was a new flavone and the other was a flavanone. Both compounds were firstly separated from natural plant. The isolation work was guided by the antioxidant activity. Both the compounds showed a significant antioxidant activity in vitro and a protective effect on dopamine-induced neurotoxicity in PC12 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Dopamine / pharmacology
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Ferns / chemistry*
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Flavanones / chemistry
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Flavanones / isolation & purification*
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Flavanones / pharmacology*
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Flavones / chemistry
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Flavones / isolation & purification*
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Flavones / pharmacology*
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology*
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PC12 Cells
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Rats
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Rhizome / chemistry
Substances
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(2S)-5,2',5'-trihydroxy-7-methoxyflavanone
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5,2',5'-trihydroxy-7-methoxyflavone
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Antioxidants
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Flavanones
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Flavones
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Neuroprotective Agents
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Dopamine