Neuropective constituents from the rhizomes of Abacopteris penangiana

J Asian Nat Prod Res. 2011 Aug;13(8):707-13. doi: 10.1080/10286020.2011.586340.

Abstract

Two neuropective compounds were isolated from the rhizomes of Abacopteris penangiana, one was a new flavone and the other was a flavanone. Both compounds were firstly separated from natural plant. The isolation work was guided by the antioxidant activity. Both the compounds showed a significant antioxidant activity in vitro and a protective effect on dopamine-induced neurotoxicity in PC12 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology*
  • Dopamine / pharmacology
  • Ferns / chemistry*
  • Flavanones / chemistry
  • Flavanones / isolation & purification*
  • Flavanones / pharmacology*
  • Flavones / chemistry
  • Flavones / isolation & purification*
  • Flavones / pharmacology*
  • Molecular Structure
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification*
  • Neuroprotective Agents / pharmacology*
  • PC12 Cells
  • Rats
  • Rhizome / chemistry

Substances

  • (2S)-5,2',5'-trihydroxy-7-methoxyflavanone
  • 5,2',5'-trihydroxy-7-methoxyflavone
  • Antioxidants
  • Flavanones
  • Flavones
  • Neuroprotective Agents
  • Dopamine