Effective cell uptake of nanoassemblies of a fluorescent amphiphilic cyclodextrin and an anionic porphyrin

Chem Commun (Camb). 2011 Aug 28;47(32):9140-2. doi: 10.1039/c1cc12821c. Epub 2011 Jul 13.

Abstract

An emitting nanoassembly composed of a novel amphiphilic cyclodextrin functionalised with a covalently appended fluorophore and an anionic porphyrin internalizes effectively in tumor cells, allowing simultaneously the detection of carrier and photosensitiser.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions / chemistry
  • Anions / metabolism
  • Cell Line, Tumor
  • Cell Membrane Permeability
  • Cyclodextrins / chemistry*
  • Cyclodextrins / metabolism
  • Drug Carriers / chemistry*
  • Drug Carriers / metabolism
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / metabolism
  • Hep G2 Cells
  • Humans
  • Nanostructures / chemistry
  • Photosensitizing Agents / administration & dosage*
  • Porphyrins / chemistry*
  • Porphyrins / metabolism

Substances

  • Anions
  • Cyclodextrins
  • Drug Carriers
  • Fluorescent Dyes
  • Photosensitizing Agents
  • Porphyrins