Cytotoxic sesquiterpenoids from the fruits of Lindera communis

Zhipeng Deng; Hao Zhong; Shuxiang Cui; Fengling Wang; Yanying Xie; Qingqiang Yao

doi:10.1016/j.fitote.2011.06.012

Cytotoxic sesquiterpenoids from the fruits of Lindera communis

Fitoterapia. 2011 Oct;82(7):1044-6. doi: 10.1016/j.fitote.2011.06.012. Epub 2011 Jul 2.

Authors

Zhipeng Deng¹, Hao Zhong, Shuxiang Cui, Fengling Wang, Yanying Xie, Qingqiang Yao

Affiliation

¹ Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, 250062, China.

PMID: 21749916
DOI: 10.1016/j.fitote.2011.06.012

Abstract

A new sesquiterpenoid, namely Linerenone (1), together with three known sesquiterpenoids (2-4), were isolated from the fruits of Lindera communis. Their structures were determined by extensive spectroscopic analysis including 1D, 2D-NMR and HR-MS spectra. Compound 1 showed significant cytotoxic activity against H460, ES2 and DU145 cancer cells with IC(50) of 2.1 μg/mL, 2.8 μg/mL and 3.0 μg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use*
Cell Line, Tumor
Fruit
Humans
Lindera / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Neoplasms / drug therapy*
Phytotherapy*
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology
Sesquiterpenes / therapeutic use*

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Sesquiterpenes
linerenone