Evaluation of four rapid diagnostic tests for the diagnosis of Plasmodium vivax in Korea

Trop Med Int Health. 2011 Nov;16(11):1427-31. doi: 10.1111/j.1365-3156.2011.02846.x. Epub 2011 Jul 12.

Abstract

Objective: To evaluate 4 rapid malaria diagnostic kits (RDTs) in Korea: OptiMAL test, SD BIOLINE Malaria Ag P.f/Pan test, Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test.

Methods: Hundred malaria patients with Plasmodium vivax (P. vivax) and 100 healthy volunteers were recruited. The results from earlier four RDTs were compared with the reference standard, the Giemsa-stained traditional microscopic diagnosis.

Results: Compared with the reference standard, the sensitivity and specificity for Plasmodium vivax were 92.7 and 100% for SD BIOLINE Malaria Ag P.f/Pan; and 94.6% and 100% for OptiMAL; 95.5% and 100% for both Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test.

Conclusion: The performances of all four malaria RDT kits were acceptable, although Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test gave superior performances with ROK isolates.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Diagnostic Tests, Routine / methods*
  • Humans
  • Malaria, Vivax / diagnosis*
  • Plasmodium vivax / isolation & purification*
  • Predictive Value of Tests
  • Reagent Kits, Diagnostic / standards*
  • Republic of Korea
  • Sensitivity and Specificity
  • Young Adult

Substances

  • Reagent Kits, Diagnostic