Electrostatically assembled biocompatible polymer nanoparticles for MR/optical dual-modality imaging nanoprobes

Chem Commun (Camb). 2011 Aug 21;47(31):8889-91. doi: 10.1039/c1cc11922b. Epub 2011 Jul 11.

Abstract

Biocompatible dual-modality imaging nanoprobes were synthesized by the electrostatic assembly of poly(γ-glutamic acid)[Gd-DTPA] and chitosan[IRDye800] and applied for the imaging of immune cells (phagocytic) and cancer cells (non-phagocytic).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Cell Line, Tumor
  • Chitosan / chemistry
  • Gadolinium DTPA / chemistry
  • Humans
  • Indoles / chemistry
  • Magnetic Resonance Imaging
  • Mice
  • Microscopy, Fluorescence
  • Nanoparticles / chemistry*
  • Polyglutamic Acid / analogs & derivatives
  • Polyglutamic Acid / chemistry
  • Polymers / chemistry*
  • Static Electricity

Substances

  • Biocompatible Materials
  • IRDye800
  • Indoles
  • Polymers
  • poly(gamma-glutamic acid)
  • Polyglutamic Acid
  • Chitosan
  • Gadolinium DTPA