Discovery of new eunicellins from an Indonesian octocoral Cladiella sp

Yung-Husan Chen; Chia-Ying Tai; Yin-Di Su; Yu-Chia Chang; Mei-Chin Lu; Ching-Feng Weng; Jui-Hsin Su; Tsong-Long Hwang; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/md9060934

Discovery of new eunicellins from an Indonesian octocoral Cladiella sp

Mar Drugs. 2011;9(6):934-943. doi: 10.3390/md9060934. Epub 2011 May 26.

Authors

Yung-Husan Chen¹, Chia-Ying Tai^{1

2}, Yin-Di Su^{1

3}, Yu-Chia Chang^{1

4}, Mei-Chin Lu^{1

2}, Ching-Feng Weng⁵, Jui-Hsin Su^{1

2

6}, Tsong-Long Hwang⁷, Yang-Chang Wu^{8

9}, Ping-Jyun Sung^{1

2

3

5

6}

Affiliations

¹ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
² Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
³ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
⁴ Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
⁵ Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
⁶ Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
⁷ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
⁸ Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
⁹ Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan.

Abstract

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (-)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

Keywords: Cladiella; cladieunicellin; elastase; eunicellin; octocoral; superoxide anion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Humans
Indonesia
Neutrophils / drug effects
Neutrophils / enzymology
Neutrophils / metabolism
Nuclear Magnetic Resonance, Biomolecular
Pancreatic Elastase / metabolism
Spectrum Analysis / methods
Superoxides / metabolism

Substances

Anti-Inflammatory Agents, Non-Steroidal
Diterpenes
eunicellin
Superoxides
Pancreatic Elastase