A new 1,3-diketofriedelane triterpene from Salacia verrucosa

Pathom Somwong; Rutt Suttisri; Anumart Buakeaw

doi:10.1016/j.fitote.2011.06.007

A new 1,3-diketofriedelane triterpene from Salacia verrucosa

Fitoterapia. 2011 Oct;82(7):1047-51. doi: 10.1016/j.fitote.2011.06.007. Epub 2011 Jul 2.

Authors

Pathom Somwong¹, Rutt Suttisri, Anumart Buakeaw

Affiliation

¹ Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

PMID: 21745551
DOI: 10.1016/j.fitote.2011.06.007

Abstract

A new 1,3-diketofriedelane triterpene, 21α-hydroxyfriedelane-1,3-dione (1) together with six known friedelane triterpenes, 30-hydroxyfriedelane-1,3-dione (2), friedelane-1,3-dione (3), 26-hydroxyfriedelane-1,3-dione (4), friedelin (5), 21α-hydroxy-D:A-friedo-olean-3-one (6) and kokoonol (7), were isolated from the stems of Salacia verrucosa (Celastraceae). The structures of these triterpenes were characterized by spectroscopic methods (IR, MS and NMR). Compound 3 was strongly cytotoxic against SW620 cell line, whereas compounds 4 and 6 were moderately active against SW620, HepG2 and KATO-III cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts / chemistry*
Salacia / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification*

Substances

21alpha-hydroxyfriedelane-1,3-dione
Plant Extracts
Triterpenes
friedelane