Antibacterial polyketides from the jellyfish-derived fungus Paecilomyces variotii

J Nat Prod. 2011 Aug 26;74(8):1826-9. doi: 10.1021/np200350b. Epub 2011 Jul 11.

Abstract

Four new polyketides (1-4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. The compounds showed inhibitory activity against pathogenic bacteria including methicillin-resistant Staphylococcus aureus 3089 and multi-drug-resistant Vibrio parahemolyticus 7001 with MIC values in the range 5-40 μg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Benzofurans / pharmacology
  • Drug Resistance, Multiple / drug effects
  • Indans / chemistry
  • Indans / isolation & purification*
  • Indans / pharmacology
  • Macrolides / chemistry
  • Macrolides / isolation & purification*
  • Macrolides / pharmacology
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oceans and Seas
  • Paecilomyces / chemistry*
  • Scyphozoa / microbiology*
  • Vibrio parahaemolyticus / drug effects

Substances

  • Anti-Bacterial Agents
  • Benzofurans
  • Indans
  • Macrolides