No influence on disease progression of non-HLA susceptibility genes in MS

Wangko Lundström; Eva Greiner; Frida Lundmark; Helga Westerlind; Cathrine Smestad; Aslaug R Lorentzen; Ingrid Kockum; Jenny Link; Boel Brynedal; Elisabeth G Celius; Hanne F Harbo; Thomas Masterman; Jan Hillert

doi:10.1016/j.jneuroim.2011.05.003

No influence on disease progression of non-HLA susceptibility genes in MS

J Neuroimmunol. 2011 Aug 15;237(1-2):98-100. doi: 10.1016/j.jneuroim.2011.05.003. Epub 2011 Jul 13.

Authors

Wangko Lundström¹, Eva Greiner, Frida Lundmark, Helga Westerlind, Cathrine Smestad, Aslaug R Lorentzen, Ingrid Kockum, Jenny Link, Boel Brynedal, Elisabeth G Celius, Hanne F Harbo, Thomas Masterman, Jan Hillert

Affiliation

¹ The Multiple Sclerosis Research group, Centre for Molecular Medicine, Department of Clinical neuroscience, Karolinska Institutet, Stockholm, Sweden. wangko.lundstrom@ki.se

PMID: 21742385
DOI: 10.1016/j.jneuroim.2011.05.003

Abstract

Recently, several non-HLA loci have been shown to be convincingly associated with Multiple Sclerosis (MS) susceptibility, assumingly indicating important pathways in the pathogenesis. A genotype influence on disease outcome measures by these genes would support a role of these pathways in ongoing tissue damage. Here, however, we report a consistent dissociation between causation and progression for five non-HLA genotypes (IL7R, IL2RA, CLEC16A, CD226 and SH2B3) in 1776 Scandinavian MS patients.

MeSH terms

Adaptor Proteins, Signal Transducing
Adult
Antigens, Differentiation, T-Lymphocyte / genetics
Antigens, Differentiation, T-Lymphocyte / immunology
Antigens, Surface / genetics*
Antigens, Surface / immunology*
Disease Progression
Female
Genetic Predisposition to Disease / ethnology
Genetic Predisposition to Disease / genetics*
HLA Antigens / immunology
Humans
Interleukin-2 Receptor alpha Subunit / genetics
Interleukin-2 Receptor alpha Subunit / immunology
Intracellular Signaling Peptides and Proteins
Lectins, C-Type / genetics
Lectins, C-Type / immunology
Male
Monosaccharide Transport Proteins / genetics
Monosaccharide Transport Proteins / immunology
Multiple Sclerosis / genetics*
Multiple Sclerosis / immunology*
Multiple Sclerosis / pathology
Norway / epidemiology
Proteins / genetics
Proteins / immunology
Receptors, Interleukin-7 / genetics
Receptors, Interleukin-7 / immunology
Sweden / epidemiology

Substances

Adaptor Proteins, Signal Transducing
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface
CD226 antigen
CLEC16A protein, human
HLA Antigens
IL2RA protein, human
Interleukin-2 Receptor alpha Subunit
Intracellular Signaling Peptides and Proteins
Lectins, C-Type
Monosaccharide Transport Proteins
Proteins
Receptors, Interleukin-7
SH2B3 protein, human