In vitro evaluation of hexagonal polymeric micelles in macrophage phagocytosis

Hsieh-Chih Tsai; Che-Hau Chang; Yie-Chan Chiu; Shuian-Yin Lin; Che-Ping Lin; Ging-Ho Hsiue

doi:10.1002/marc.201100157

In vitro evaluation of hexagonal polymeric micelles in macrophage phagocytosis

Macromol Rapid Commun. 2011 Sep 15;32(18):1442-6. doi: 10.1002/marc.201100157. Epub 2011 Jul 5.

Authors

Hsieh-Chih Tsai¹, Che-Hau Chang, Yie-Chan Chiu, Shuian-Yin Lin, Che-Ping Lin, Ging-Ho Hsiue

Affiliation

¹ Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC. h.c.tsai@mail.ntust.edu.tw

PMID: 21732463
DOI: 10.1002/marc.201100157

Abstract

This paper develops a non-spherical polymeric micelle using an amphiphilic block copolymer and a porphyrin crystalline structure. The nanoscale polymer micelles were characterized by transmission electron microscopy (TEM) and atomic force microscopy (AFM), revealing particle sizes of approximately 150 nm with a particular shape in the hexagonal lattice. The shape shows the selective uptake efficacy for the HeLa and macrophage cells, and inhibits phagocytosis against the macrophage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers / chemical synthesis
Drug Carriers / chemistry*
Drug Carriers / pharmacology
Drug Delivery Systems / instrumentation*
HeLa Cells
Humans
Macrophages / drug effects
Macrophages / physiology*
Micelles
Particle Size
Phagocytosis* / drug effects
Polymers / chemical synthesis
Polymers / chemistry*
Polymers / pharmacology

Substances

Drug Carriers
Micelles
Polymers