Treatment of Kaposi sarcoma in human immunodeficiency virus-1-infected Mozambican children with antiretroviral drugs and chemotherapy

Pediatr Infect Dis J. 2011 Oct;30(10):891-3. doi: 10.1097/INF.0b013e318228fb04.

Abstract

AIDS-associated Kaposi sarcoma occurs in children, but treatment experience reports are very scarce. A retrospective analysis of 28 children treated with highly active antiretroviral therapy and monthly paclitaxel showed unexpected results with 19 children in complete and sustainable remission, including those with the most severe form. Tolerance and feasibility were good, despite a lack of skilled staff in a low-resource setting.

MeSH terms

  • Adolescent
  • Anti-Retroviral Agents / administration & dosage*
  • Antineoplastic Agents / administration & dosage*
  • Antiretroviral Therapy, Highly Active / methods*
  • Child
  • Child, Preschool
  • Drug Therapy / methods*
  • Female
  • HIV Infections / complications*
  • HIV Infections / virology
  • HIV-1 / isolation & purification
  • Humans
  • Male
  • Mozambique
  • Sarcoma, Kaposi / drug therapy*
  • Sarcoma, Kaposi / pathology
  • Treatment Outcome

Substances

  • Anti-Retroviral Agents
  • Antineoplastic Agents