Abstract
A sildenafil analogue was detected and isolated from a health supplement claimed for human use. The structure of this new analogue was elucidated using LC-UV, LC-Orbitrap-MS, IR spectroscopy, 1D and 2D NMR. It was characterized as dithio-desmethylcarbodenafil containing 2 thiocarbonyl groups instead of 2 carbonyl groups, and 4-methyl substitution, on the piperazine ring, rather than 4-ethyl substitution, when compared to sildenafil.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Chromatography, Liquid / methods
-
Dietary Supplements / analysis*
-
Drug Contamination*
-
Humans
-
Magnetic Resonance Spectroscopy / methods
-
Mass Spectrometry / methods
-
Piperazine
-
Piperazines / chemistry*
-
Piperazines / isolation & purification
-
Purines / chemistry
-
Purines / isolation & purification
-
Sildenafil Citrate
-
Spectrophotometry, Infrared / methods
-
Spectrophotometry, Ultraviolet / methods
-
Sulfones / chemistry*
-
Sulfones / isolation & purification
Substances
-
Piperazines
-
Purines
-
Sulfones
-
Piperazine
-
Sildenafil Citrate